Is Down syndrome inherited?

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  • The two most common forms of Down syndrome, Trisomy 21 and Mosaic, which make up approximately 96% of cases, are not inherited.
  • Robertsonian/Translocation Down syndrome can be inherited but it can also be spontaneous.  
  • The chance of having another baby with Down syndrome is very small, only slightly higher than usual. 
  • Other family members (the baby’s siblings, aunts and cousins) do not have an increased chance of having a baby with Down syndrome. 
  • Very few people with Down syndrome have been known to have children.  If they do have children, the chance of them having a baby with Down syndrome is high.